Bioactive Small Molecules
Medchemexpress LLC BAY-9835 | 3032487-31-0 | 99.5% | 493.39 | 25 MG
BAY-9835 is a chemical probe and an orally active ADAMTS7 and ADAMTS12 antagonist with IC50s of 6 nM and 30 nM, respectively. It shows inhibitory potencies against mouse (mIC50 = 8 nM) and rat (rIC50 = 27 nM) ADAMTS7 enzymes. BAY-9835 is highly selective against various off-targets and metalloproteases and can be used for the study of atherogenesis.
- IC50s of 6 nM for ADAMTS7 and 30 nM for ADAMTS12.
- Inhibitory potencies against mouse (8 nM) and rat (27 nM) ADAMTS7 enzymes.
- High selectivity against off-targets and metalloproteases.
- High metabolic stability with human microsomes.
- No inhibition of CYP1A2, 2C8, 2C9, 2D6, and 3A4 enzymes or cardiac ion channels (< 20 μM).
- Well tolerated in mice with no adverse effects at 50 mg/kg.
Medchemexpress LLC 7-bromoindirubin-3-oxime | 916440-85-2 | 99.2% | 50MG
7-bromoindirubin-3-oxime | 916440-85-2 | 99.2% | 50MG
Medchemexpress LLC (4-(tert-Butoxycarbonyl)phenyl)boronic acid | 850568-54-6 | 99.6% | 222.05 | 10 G
(4-(tert-Butoxycarbonyl)phenyl)boronic acid is a biochemical reagent used in life science research. It can serve as a biological material or organic compound, enabling various experimental applications. This compound is for research use only and not intended for patient use.
- Biochemical reagent for life science research
- Mediates ortho specific hydroxylalkylation of phenols by aldehydes
- Utilized for fluorescent detection of saccharides by binding diol functional groups
- Effective catalyst for amidation and esterification of carboxylic acids
Selleck Chemical LLC Corilagin S9090-1MG
Corilagin discovered in many medicinal plants such as Phyllanthus speices etc has multiple activities including anti-oxidative anti-inflammatory anti-apoptotic hepatoprotective and others It is an inhibitor of TNF-
Selleck Chemical LLC PDD00017273 S8862-100MG
PDD00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor with an IC50 of 26 nM PDD00017273 exhibits 350-fold selectivity for PARG over a panel of ion channels enzymes and receptors including PARP1 and ARH3
Medchemexpress LLC KRAS G12D inhibitor 26 | 2972625-49-1 | 98.4% | 663.23 | 5 MG
KRAS G12D inhibitor 26 is a modulator of Kras, specifically targeting Kras(G12D) with an IC50 ≤ 100 nM. This product is for research use only.
- Modulator of Kras, targeting Kras(G12D) with an IC50 ≤ 100 nM.
Medchemexpress LLC 1-Benzopyrylium, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-, chloride (1:1) | 528-58-5 | MFCD00017582 | 322.70 | 25 MG
Cyanidin Chloride (IdB 1027) is a subclass of anthocyanin that displays antioxidant and anti-carcinogenesis properties. It is known to inhibit osteoclast formation, hydroxyapatite resorption, and receptor activator of NF-κB ligand (RANKL)-induced osteoclast marker gene expression.
- Antioxidant properties.
- Anti-carcinogenesis properties.
- Inhibits osteoclast formation.
- Inhibits hydroxyapatite resorption.
- Inhibits RANKL-induced osteoclast marker gene expression.
eMolecules 1094042-01-9 | Medchem Express | CYM5442 | 5mg | 569407729 | HY-10968 | MFCD12912402 | 409.486 | C23H27N3O4
Ambeed | 4-Chloro-2-fluoro-3-methoxybenzoic acid | 250mg | 600843084 | A559920 | 1169870-80-7 | MFCD19687204 | 204.580 | C8H6ClFO3
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Cayman Chemical ANTIBODY Os-128167 10mg
A SIRT6 inhibitor (IC50 = 89 μM); selective for SIRT6 over SIRT1 and 2 (IC50s = 1,578 and 751 μM, respectively); increases H3K9 acetylation and glucose uptake and decreases TNF-α release in BxPC-3 cells; prevents bexarotene-induced decreases in left hemisphere cerebral levels of IL-1β, TNF-α, and IL-6 and neutrophil infiltration in a rat model of subarachnoid hemorrhage at 100 μg/animal, i.c.v.
![Medchemexpress LLC 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | 1062368-24-4 | >98.0% | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230396.png-250.jpg)
Medchemexpress LLC 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | 1062368-24-4 | >98.0% | 50 MG
LDN193189 (GMP) is a GMP-grade small-molecule inhibitor of BMP type I receptors, supplied as a research reagent intended for use as an auxiliary reagent in cell therapy manufacture and regulated research. The compound has molecular formula C25H22N6 and molecular weight 406.49 g/mol, and is provided in a 50 MG package.
- GMP-grade formulation suitable as an auxiliary reagent in cell therapy manufacture.
- Selective BMP type I receptor inhibitor for research applications.
- CAS 1062368-24-4 and molecular formula C25H22N6.
- Provided as a 50 MG package for controlled dosing and handling.
- Analytical purity greater than 98.0% by HPLC (supplier reported).
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC HY-N0037 5mg Medchemexpress, Albiflorin CAS:39011-90-0 Purity:>98%
Medchemexpress, HY-N0037 5mg Albiflorin CAS:39011-90-0 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Gentiopicroside | 20831-76-9 | 356.32 | 25 MG
Gentiopicroside is a naturally occurring iridoid glycoside that inhibits P450 activity and exhibits anti-inflammatory and antioxidative effects.
- Naturally occurring iridoid glycoside
- Inhibits P450 activity
- Has anti-inflammatory effects
- Has antioxidative effects
- Inhibits RANKL-induced osteoclast formation
- Blocks expression of osteoclast-related proteins
- Prevents RANKL-triggered JNK and NF-κB activation
- Inhibits RANKL-induced bone resorption
- Reduces gastric ulcer index (in vivo)
Cayman Chemical EthylD-GlucuronIde-d5 5mg
An internal standard for the quantification of ethyl-β-D-glucuronide by GC- or LC-MS
Selleck Chemical LLC AG-270 S9872-25MG
AG-270 is a potent and non-competitive methionine adenosyltransferase 2A (MAT2A) inhibitor which lessens the intracellular SAM levels and MTAP-null selective antiproliferative activity
Selleck Chemical LLC Corylin S9298-1MG
Corylin a main compound isolated from Psoralea corylifolia L (Fabaceae) has a variety of pharmacological effects such as antioxidant anti-proliferation and anti-inflammatory properties